Nothing happens without the permission of Allah swt. So in that sense I wouldn't feel a loss of a spirtual connection because I know that Allah swt has allowed this to happen to me and there are various other avenues to gain a spiritual connection. However in saying that, the Prophet PBUH did say the closest a person can become to his Lord is during prostration so in that sense I would. But I know if Allah swt took the ability and also blessing of being able to prostate to him away from me, he is either teaching me a lesson to make me realise the importance of sujood, something I take for granted in my life. Or if he has taken away this blessing, then he bless me with something else.
In relation to your question, prostration is of course pivotal, because we do it in our daily prayers which is obligatory. Various Ulama have agreed that if one is no able to stand in Salah then do it sitting, if one is not able to sit, then lie down, if they are unable to pray lying down, then they can pray with their head, if they are unable to do that then they can pray with their eyes.