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Five children among dead and 30 missing after 6.3-magnitude quake hits 70 miles north-east of Rome.
At least 27 people were killed and 30 left missing after a strong earthquake struck central Italy early this morning, destroying and damaging thousands of buildings and leaving many people homeless.
At least five children were among those who died as the 6.3-magnitude tremor shook the region at 3.32am (2.32am BST), with an epicentre directly below L'Aquila, a city of about 70,000 residents and the historic capital of the mountainous Abruzzo region.
The confirmed death toll is now 27, Italy's Ansa news agency said, citing local hospital officials.
However, with the tremor occurring as people slept and significant damage reported both inside L'Aquila and in surrounding villages, the final toll is likely to rise, which would make the quake the deadliest in Italy for almost 30 years.
"I woke up hearing what sounded like a bomb," Angela Palumbo, 87, said as she took shelter outside in L'Aquila.
"We managed to escape with things falling all around us. Everything was shaking, furniture falling. I don't remember ever seeing anything like this in my life," she told Reuters.
Rubble was littered throughout the 13th-century city and elsewhere in the region, blocking roads and hampering rescue attempts.
Dozens of injured people were waiting outside the main hospital in L'Aquila, which was only partly open after suffering damage, according to local reports.
Another hospital was closed due to fears for its structural safety and those most seriously hurt were being flown by helicopter to other cities.
More than 10,000 buildings were damaged, leaving many homeless, said Agostino Miozzo, an official with Italy's civil protection department.
"This means that the we'll have several thousand people to assist over the next few weeks and months," he told Sky Italia. "Our goal is to give shelter to all by tonight."
Italy's prime minister, Silvio Berlusconi, declared the region a disaster area and announced he was cancelling a scheduled trip to Russia.
Firefighters aided by dogs were trying to rescue people from crumbled homes in L'Aquila, including a student dormitory where half a dozen students remained trapped, RAI state TV reported.
"We managed to come down with other students but we had to sneak through a hole in the stairs as the whole floor came down," said one student Luigi Alfonsi, 22.
"I was in bed. It was like it would never end as I heard pieces of the building collapse around me."
Four children were reported killed in one building in L'Aquila. Two people died in one outlying village and five in another.
Television footage from the scene showed residents and rescue workers hauling away debris from collapsed buildings and bloodied residents waiting to be tended to in hospital hallways.
The mayor of L'Aquila, Massimo Cialente, told Italian television that two other people were reported dead in the nearby small town of Fossa. He confirmed reports that another eight were missing in another small town.
The Ansa news agency said the dome of a church in L'Aquila collapsed, while the city's cathedral also suffered damage.
The quake was the latest in a series of jolts that struck the area over the last two days.
The last major Italian earthquake was in 2002, when 27 children and one adult died after a school collapsed in Molise, in the south of the country. In November 1980, a severe quake hit an area near Naples, killing 2,570 people.
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