A stronger i.e physically bigger, taller muscular person will generally take more punishment as they have that extra padding. I know myself because I used to be about 69 kg and after going to the gym about a year I reached 77 kg and hits and/or hits to parts of the body that were not sensitive were not as painful as before. Try ripping a massive Tongan in the guts for example and hell laugh at you. So in the end it would be a matter of quickly wearing him down with a number of attacks aimed for maximum damage, as mentioned before nose, ears, solar plexus, groin e.t.c Joint breaking is a perfect way to disable a large person. No matter how much muscle you have you cannot strengthen joints. as there is no muscle where joint is. You can strengthen tendons and ligaments but not to the point were a full force arm lock won't work. Another tried and tested technnique in our martial arts school is a finger inserted just below the adams apple in a gap between the collarbone and the windpipe. If it can be done as it may prove difficult for some people to locate while trying to fend off an attacker, it can cause extreme discomfort and panic, so much so that the attacker will have No choice but to step back from you if you manage to hit the spot with a knife hand strike it will cause difficulty breathing but will not be fatal unlike a strike to the adams apple. :thumbs_up
actually it was meant to be a SPEAR HAND strike not a knif hand strike.